With the Pride gone, every bad guy in the Marvel Universe is trying to fill the void they left behind. The Runaways are the only heroes who can stop them. And what team of young heroes is looking for the Runaways and why?
Returning to Los Angeles, after escaping catastrophe in New York City, the Runaways must protect one of their own when soldiers from Karolina's home planet accuse her of genocide and plan to capture her for punishment.
The kids start running in a different direction. The Runaways take off for the Big Apple. While there, they make surprising allies and even more surprising enemies with a journey through time. Plus, what happens when the teens meet...the Punisher!?