Heartbroken after her best friend and soul mate, Fang, leaves her flock, Maximum Ride begins to believe the evil scientists trying to convince her she needs to save the world, and that Dylan, the newest member of her flock, is her perfect mate.

After the mutant Erasers abduct the youngest member of their group, the "bird kids," who are the result of genetic experimentation, take off in pursuit and find themselves struggling to understand their own origins and purpose.